Ku-Zyme (Koichi)
Ku-Zyme (Koichi) - General Information
Protein mixture isolated from porcine or bovine pancreas, sometimes called pancreatin. Contains 3 enzymes, amylase, lipase and a protease (chymotrypsin).
Pharmacology of Ku-Zyme (Koichi)
Used in the treatment of cystic fibrosis or pancreatic dysfunction, pancrelipase helps improve fat digestion in the small intestine. Specifically, the lipase, protease and amylase components break down fat, protein, and starches, respectively, in the small intestine. Lipase hydrolyzes fats into glycerol and fatty acids. Protease converts proteins into proteoses and derived substances, while amylase converts starches into dextrins and sugars. Pancreatic enzymes are used to correct maldigestion, malabsorption and pain associated with pancreatic insufficiency. The major maldigestion/malabsorption problems arise from incomplete fat digestion. Exogenous pancrelipase reduces the amount of nitrogen and fat excreted in the stool.
Ku-Zyme (Koichi) for patients
Ku-Zyme (Koichi) Interactions
Ku-Zyme (Koichi) Contraindications
PANCRECARB (pancrelipase) delayed-release capsules are contraindicated in patients known to be hypersensitive to pork protein. PANCRECARB (pancrelipase) delayed-release capsules are contraindicated in patients under treatment for acute pancreatitis.
Additional information about Ku-Zyme (Koichi)
Ku-Zyme (Koichi) Indication: For treatment of cystic fibrosis, chronic pancreatitis, pancreatic duct blockage
Mechanism Of Action: The lipase, protease and amylase components of pancrelipase break down fat, protein, and starches, respectively, in the small intestine. Lipase hydrolyzes fats into glycerol and fatty acids. Protease converts proteins into proteoses and derived substances, while amylase converts starches into dextrins and sugars.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Pancrelipase
Synonyms: 1,4-alpha-D- glucan glucanohydrolase; PA; Pancreatic alpha-amylase precursor
Drug Category: Enzyme Replacement Agents
Drug Type: Biotech; Approved
Other Brand Names containing Pancrelipase: Cotazym (Organon); Ku-Zyme (Koichi); Pancrease (Ortho-McNeil); Ultrase (Axcan Scandipharm); Zymase (Organon);
Absorption: Not Available
Toxicity (Overdose): Not Available
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of Ku-Zyme (Koichi): Capsule, coated Oral
Chemical IUPAC Name: Not Available
Chemical Formula: C5850H8902N1606O1739S49
Pancrelipase on Wikipedia: https://en.wikipedia.org/wiki/Pancrelipase
Organisms Affected: Humans and other mammals